A Case-Control Study to Investigate Serological Correlates of Clinical Failure of 23-Valent Pneumococcal Polysaccharide Vaccine in HIV-1鈥搃nfected Ugandan Adults.

From:
Foreign, Commonwealth & Development Office
Published
1 January 2004
Country:
Uganda
Document Type:
Journal Article
Theme:
Health
First published:
1 January 2004
Authors:
Moore, M., Gilks, C.F., French, N., Haikala, R. and K盲yhty, H.

Abstract

We have investigated the association between the concentration of anti鈥損olysaccharide pneumococcal capsule鈥搒pecific (anti鈥怭S) immunoglobulin G and the killing activity, in serum, in invasive pneumococcal disease (IPD) events and response to 23鈥恦alent polysaccharide vaccine in human immunodeficiency virus (HIV)鈥搃nfected Ugandans. Case patients with IPD had lower concentrations of anti鈥怭S IgG before and after vaccination and before the IPD event (PP=0.08), and for 23F, it was detected in 11% of case patients versus 40% of control subjects (P=0.02). Thus, absolute concentration of anti鈥怭S IgG and an attenuated response to polysaccharide are associated with risk of IPD in HIV鈥恑nfected adults.

Citation

Journal of Infectious Diseases (2004) 190(4) pp. 707-712 [DOI:10.1086/421911]

Updates to this page

Published 1 January 2004
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